Blood-Brain Barrier Test May Predict Dementia

Cognitive impairment is when a person has problems remembering, learning, concentrating, or making decisions that affect everyday life. Millions of people in the U.S. show some sort of cognitive impairment. People with cognitive impairment are at higher risk for developing dementia, which is the loss of cognitive functioning. Alzheimer's disease is the most common dementia diagnosis.

Researchers have been looking for ways to test for early signs of cognitive impairment and dementia. Early detection could open the door to strategies that prevent disease progression. Potential biomarkers include changes in the size and function of the brain and its parts, as well as levels of certain proteins seen on brain scans, in cerebrospinal fluid, and in blood. People with Alzheimer’s disease, for example, have abnormally high levels of plaques made up of beta-amyloid and tangles made of tau proteins.

To look for earlier biomarkers of cognitive decline, a team led by Dr. Berislav V. Zlokovic at the University of Southern California, Los Angeles, examined two markers involved in the breakdown of the blood-brain barrier. This barrier controls the movement of cells and molecules between the blood and the fluid that surrounds the brain’s nerve cells. Past studies have found that abnormalities in the small blood vessels (capillaries) of the brain often contribute to dementia.

The team enrolled more than 160 people with and without cognitive impairment. They measured levels of the soluble form of a protein called platelet-derived growth factor receptor beta (PDGFRβ). PDGFRβ is found in the capillaries that maintain the blood-brain barrier’s integrity. Levels of the soluble form rise in cerebrospinal fluid when the blood-brain barrier is compromised. The team also tracked the integrity of the blood-brain barrier in 73 participants using an MRI-based technique they’d previously developed. The study was supported in part by NIH’s National Institute on Aging (NIA) and National Institute of Neurological Disorders and Stroke (NINDS). Results were published online on January 14, 2018, in Nature Medicine. 

Read more: Blood-Brain Barrier Test May Predict Dementia

Real Life Benefits of Exercise and Physical Activity for Caregivers

exercise benefitsIf you are a caregiver for an dementia patient or other elderly person, your best defense against mental and physical health disorders is taking care of yourself. 

Exercise and physical activity aren’t just good for your mind and body, it can help you stay active and mobile as you age! Regularly including all 4 types of exercise will give you a wide range of real-life benefits.

Endurance activities help you:

  • Keep up with your grandchildren during a trip to the park.
  • Dance to your favorite songs at the next family wedding.
  • Rake the yard and bag up the leaves.

Read more: Real Life Benefits of Exercise and Physical Activity for Caregivers

Holiday Hints for Alzheimer's Caregivers

Holidays can be meaningful, enriching times for both the person with Alzheimer’s disease and his or her family. Maintaining or adapting family rituals and traditions helps all family members feel a sense of belonging and family identity. For a person with Alzheimer’s, this link with a familiar past is reassuring.

However, when celebrations, special events, or holidays include many people, this can cause confusion and anxiety for a person with Alzheimer’s. He or she may find some situations easier and more pleasurable than others. The tips below can help you and the person with Alzheimer’s visit and reconnect with family, friends, and neighbors during holidays. 

Finding the Right Balance

Many caregivers have mixed feelings about holidays. They may have happy memories of the past, but they also may worry about the extra demands that holidays make on their time and energy.

Here are some ways to balance doing many holiday-related activities while taking care of your own needs and those of the person with Alzheimer’s disease:

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  1. Celebrate holidays that are important to you. Include the person with Alzheimer’s as much as possible.
  2. Set your own limits, and be clear about them with others. You do not have to live up to the expectations of friends or relatives. Your situation is different now.
  3. Involve the person with Alzheimer’s in simple holiday preparations, or have him or her observe your preparations. Observing you will familiarize him or her with the upcoming festivities. Participating with you may give the person the pleasure of helping and the fun of anticipating and reminiscing.
  4. Consider simplifying your holidays around the home. For example, rather than cooking an elaborate dinner, invite family and friends for a potluck. Instead of elaborate decorations, consider choosing a few select items.
  5. Encourage friends and family to visit even if it’s difficult. Limit the number of visitors at any one time, or have a few people visit quietly with the person in a separate room. Plan visits when the person usually is at his or her best.
  6. Prepare quiet distractions to use, such as a family photo album, if the person with Alzheimer’s becomes upset or overstimulated.
  7. Make sure there is a space where the person can rest when he or she goes to larger gatherings.
  8. Try to avoid situations that may confuse or frustrate the person with Alzheimer’s, such as crowds, changes in routine, and strange places. Also try to stay away from noise, loud conversations, loud music, lighting that is too bright or too dark, and having too much rich food or drink (especially alcohol).
  9. Find time for holiday activities you like to do. If you receive invitations to celebrations that the person with Alzheimer’s cannot attend, go yourself. Ask a friend or family member to spend time with the person while you’re out.

Read more: Holiday Hints for Alzheimer's Caregivers

A Serving a Day of Leafy Greens Can Help Slow Cognitive Decline

A 2018 report in the journal Neurology found that a diet containing approximately one serving of green leafy vegetables per day is associated with slower age-related cognitive decline, according to the National Institute of Health.

Researchers from Rush University in Chicago and the Tufts Human Nutrition Research Center in Boston followed 960 older adults enrolled in the Rush Memory and Aging Project.  The research team focused on the level of consumption of green leafy vegetables, like spinach, kale, collards, and lettuce, which have been suggested in previous research to have protective factors against cognitive decline (Kang et al., 2005; Morris et al., 2006), and looked at the association with performance on cognitive tests.

The average age of the participants was 81 years and all were dementia-free at the beginning of the study. Over an average of nearly 5 years, participants underwent an annual battery of tests that assessed cognition in five domains (episodic memory, working memory, semantic memory, visuospatial ability, and perceptual speed). Data from food frequency questionnaires administered at the beginning of the study were used to assess how frequently people ate some 144 items over the previous 12 months. Dietary intake levels of the nutrients of interest were estimated from responses to all food items. The three green leafy vegetable items and their serving sizes included in the questionnaire were: spinach (1/2 cup cooked), kale/collards/greens (1/2 cup cooked), and lettuce salad (1 cup raw).

Read more: A Serving a Day of Leafy Greens Can Help Slow Cognitive Decline

7 Surprising Benefits of Doing Jigsaw Puzzles for All Ages

There's a quiet movement going on in this country, and it doesn't involve apps, data or the latest fad. Following the lead of vinyl record albums, coloring books and traditional board games, jigsaw puzzles are seeing a resurgence in popularity. Perhaps, because it's an opportunity to unplug and give yourself and family an escape from the information overload that is buzzing through the very fabric of our lives 24/7.

Wrestling yourself away from screens, devices, even the television can be a nearly impossible task, but it's vital to our mental and even physical health. A jigsaw puzzle requires your full attention and therein lies the magic. Everyone from tweens and teens to millennials and over-worked parents to seniors are returning to this quiet pastime of childhood. Call it a retro revolution.

Here are some benefits of puzzling that might surprise you.

Read more: 7 Surprising Benefits of Doing Jigsaw Puzzles for All Ages

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